Article
Mutagenesis by N-nitroso compounds in Salmonella typhimurium TA102 and TA104: evidence for premutagenic adenine or thymine DNA adducts.
Mutation research - 1 Jan 2000
Guttenplan J B, Hu Y C
Abstract excerpt
Mutagenesis induced by the N-nitroso compounds: N-nitrosomethylurea, N-nitrosoethylurea, N-nitrosodi-n-propylamine and N-nitrosopyrrolidine was measured in Salmonella typhimurium TA100, TA102 and TA104. TA100 detects damage mainly at G-C base pairs while TA102 and TA104 can detect damage at A-T base pairs. In general all strains were similarly sensitive, except that TA104 was much less sensitive to high doses of...
Topics
- Adenine
- Animals
- Base Composition
- Biotransformation
- DNA, Bacterial
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Nitroso Compounds
- Rats