Article
DNA-damaging effects of genotoxins in mixture: nonadditive effects of aflatoxin B1 and N-acetylaminofluorene on their mutagenicity in Salmonella typhimurium.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 1999
Said B, Ross M K, Hamade A K, Matsumoto D C, Shank R C
Abstract excerpt
Most animal genotoxicity studies have used exposures to single chemicals; humans, however, are potentially exposed to mixtures of genotoxins. Cancer and developmental toxicity risks associated with genotoxins in mixture are generally estimated by assuming additivity of the components. Two or more genotoxins acting sequentially or simultaneously may present a greater or lesser hazard than that predicted by simple...
Topics
- 2-Acetylaminofluorene
- Acetoxyacetylaminofluorene
- Aflatoxin B1
- Alleles
- DNA Damage
- Frameshift Mutation
- Mutagenicity Tests
- Mutagens
- Salmonella typhimurium