Article
Induction of -2 frameshift mutations by 2-nitrofluorene, N-hydroxyacetylaminofluorene, and N-2-acetylaminofluorene in reversion assays in Escherichia coli strains differing in permeability and acetyltransferase activity.
Mutation research - 27 Jun 2001
Hoffmann G R, Janel-Bintz R, Fuchs R P
Abstract excerpt
The mutagenicity of 2-nitrofluorene (NF), N-hydroxyacetylaminofluorene (N-OH-AAF), and N-2-acetylaminofluorene (AAF) was measured in strains of Escherichia coli that contain a lacZ allele that reverts by -2 frameshift mutations from CG(5) to CG(4). Mutagenesis was compared in a strain having wild-type permeability and metabolism, a strain with increased permeability caused by a lipopolysaccharide-defective...
Topics
- 2-Acetylaminofluorene
- Acetyltransferases
- Alleles
- Escherichia coli
- Fluorenes
- Frameshift Mutation
- Hydroxyacetylaminofluorene
- Lac Operon
- Permeability