Article
Dinitropyrene-resistant Salmonella typhimurium are deficient in an acetyl-CoA acetyltransferase.
Chemico-biological interactions - 1 Jan 2000
Orr J C, Bryant D W, McCalla D R, Quilliam M A
Abstract excerpt
Salmonella typhimurium strain TA98NR which is sensitive to 1,8-dinitropyrene mutagenesis possesses acetyl-CoA dependent acetyltransferase activity, while a strain selected for resistance to 1,8-dinitropyrene (TA98/1, 8-DNP6) is deficient in this activity. Acetyltransferase competent strains can acetylate 1,8-diaminopyrene, forming 1-N-acetylamino-8-aminopyrene and 1,8-N,N'-diacetyldiaminopyrene. The coincidence...
Topics
- Acetyl Coenzyme A
- Acetyl-CoA C-Acetyltransferase
- Acetyltransferases
- Biotransformation
- Chromatography, High Pressure Liquid
- Drug Resistance, Microbial
- Mutagens
- Mutation
- Pyrenes
- Salmonella typhimurium