Article
Interactions between DNA polymerase and aminofluorene adducts that affect the recognition and possibly the mutagenicity of the lesions.
Biochimie - 1 Jan 2000
Moore P D, Rabkin S D, Osborn A L, Strauss B S
Abstract excerpt
Adducts of 2-aminofluorene on the C-8 position of guanine block DNA synthesis and lead to mutation. N-acetylated adducts adopt the syn conformation such that in DNA the guanine is displaced from the helix by the fluorene ring while unacetylated adducts prefer the anti conformation allowing normal base pairing of the guanine with cytosine. In vitro synthesis by both E. coli DNA polymerase I and T4 DNA polymerase...
Topics
- 2-Acetylaminofluorene
- Acetoxyacetylaminofluorene
- Avian Myeloblastosis Virus
- Bacteriophage phi X 174
- DNA Polymerase I
- DNA Replication
- DNA, Viral
- DNA-Directed DNA Polymerase
- Mutation
- RNA-Directed DNA Polymerase