Article
Contribution of human V kappa II germ-line genes to light-chain diversity.
Nature - 1 Jan 2000
Klobeck H G, Solomon A, Zachau H G
Abstract excerpt
The genetic basis of the antibody repertoire--estimated to exceed 10(6) different immunoglobulin molecules--is a major unanswered problem. The number of germ-line V kappa genes in the mouse genome is probably several hundred while the corresponding number for three out of four human V kappa subgroups (V kappa I, V kappa III and V kappa IV) is probably altogether only 15-20 (ref. 5). The kappa II proteins differ...
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