Contribution of human V kappa II germ-line genes to light-chain diversity.

doi:10.1038/309073a0

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Article

Contribution of human V kappa II germ-line genes to light-chain diversity.

Nature - 1 Jan 2000

Klobeck H G, Solomon A, Zachau H G

Abstract excerpt

The genetic basis of the antibody repertoire--estimated to exceed 10(6) different immunoglobulin molecules--is a major unanswered problem. The number of germ-line V kappa genes in the mouse genome is probably several hundred while the corresponding number for three out of four human V kappa subgr...

Topics

Amino Acid Sequence
Base Sequence
Cell Line
DNA Restriction Enzymes
Genes
Genetic Variation
Humans
Immunoglobulin Light Chains
Immunoglobulin Variable Region
Lymphocytes
Nucleic Acid Hybridization

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