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Article

The creation of diversity in the human immunoglobulin V(lambda) repertoire.

Journal of molecular biology - 25 Apr 1997

Ignatovich O, Tomlinson I M, Jones P T, Winter G

Abstract excerpt

Sequence diversity in the human antibody repertoire is generated in two steps: by the combinatorial assembly of V gene segments and by somatic hypermutation. Here, we have characterised these processes for the lambda (lambda) light chain using a library of 7600 lambda cDNA clones from peripheral...

Topics

Gene Frequency
Genetic Variation
Humans
Immunoglobulin Variable Region
Immunoglobulin lambda-Chains
Lymphocytes
Models, Genetic
Models, Molecular
Protein Conformation
Sequence Analysis, DNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9149142
DOI: 10.1006/jmbi.1997.0956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9149142-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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