Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes.

doi:10.1038/307077a0

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Article

Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes.

Nature - 1 Jan 2000

Bentley D L

Abstract excerpt

The mammalian immune system produces 10(6)-10(8) different antibody-combining sites. It has been established that three factors contribute to the diversity of immunoglobulin variable regions: multiple gene segments in the germ line, somatic recombination of these segments and somatic mutation. Ho...

Topics

Antibody Diversity
Genes
Humans
Immunoglobulin Light Chains
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Lymphocytes
Mutation
RNA, Messenger

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