Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the human Ig V lambda II gene family and analysis of V lambda II and C lambda polymorphism in systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1991

Paul E, Livneh A, Manheimer-Lory A J, Diamond B

Abstract excerpt

We report the cDNA sequence of an expressed human V lambda II gene and present an RFLP analysis of the Ig gene family defined by this clone. This V lambda II gene was expressed in a monoclonal B cell line generated from a patient with SLE by transformation with EBV. The encoded lambda L chain displays the 8.12 Id, an Id common to anti-DNA antibodies from patients with SLE. Using a coding region probe we estimate...

Topics

Alleles
Base Sequence
Cloning, Molecular
Genes, Immunoglobulin
Haplotypes
Humans
Immunoglobulin Constant Regions
Immunoglobulin Variable Region
Immunoglobulin lambda-Chains
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1680918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1680918-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the human Ig V lambda II gene family and analysis of V lambda II and C lambda polymorphism in systemic lupus erythematosus.PMID 1680918Read ↗

Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11.2/IGLV).Semantic proximity Read ↗

HindIII restriction fragment alleles of the human immunoglobulin V lambda II subgroup genes.Semantic proximity Read ↗

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus.Semantic proximity Read ↗

Contribution of human V kappa II germ-line genes to light-chain diversity.Semantic proximity Read ↗

Structure and expression of the human immunoglobulin lambda genes.Semantic proximity Read ↗

Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements.Semantic proximity Read ↗

Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas.Semantic proximity Read ↗

V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism.Semantic proximity Read ↗

Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups.Semantic proximity Read ↗

Southern blot detection of immunoglobulin lambda light chain gene rearrangements for clonality studies.Semantic proximity Read ↗

Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.