Article
Molecular characterization of J558 genes encoding tight-skin mouse autoantibodies: identical heavy-chain variable genes code for antibodies with different specificities.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 1994
Kasturi K N, Yio X Y, Bona C A
Abstract excerpt
Tight-skin mouse, a mutant strain with a single gene defect, develops cutaneous hyperplasia and specific autoantibodies, like humans affected by scleroderma. The autoantibodies produced in the tight-skin mouse are encoded primarily by heavy-chain variable (VH) genes from the J558 family. To under...
Topics
- Amino Acid Sequence
- Animals
- Antibody Specificity
- Autoantibodies
- Base Sequence
- Cloning, Molecular
- Conserved Sequence
- Crosses, Genetic
- DNA Primers
- Female
- Genes, Immunoglobulin
- Genetic Variation
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region