Article
Transforming activity of polyoma virus middle-T antigen probed by site-directed mutagenesis.
Nature - 1 Jan 2000
Oostra B A, Harvey R, Ely B K, Markham A F, Smith A E
Abstract excerpt
The ability of polyoma virus to transform cells results primarily from the action of one of the virus-coded early proteins, called middle-T antigen. Middle-T has an associated tyrosine-specific protein kinase activity that can be measured in vitro and results in the phosphorylation of middle-T it...
Topics
- Amino Acid Sequence
- Antigens, Polyomavirus Transforming
- Base Sequence
- Cell Transformation, Neoplastic
- Cloning, Molecular
- DNA Restriction Enzymes
- Genes, Viral
- Mutation
- Plasmids
- Polyomavirus
- Protein Kinases
- Protein-Tyrosine Kinases
- Viral Proteins