Article
The amino terminus of polyomavirus middle T antigen is required for transformation.
Journal of virology - 1 May 1990
Cook D N, Hassell J A
Abstract excerpt
In polyomavirus-transformed cells, pp60c-src is activated by association with polyomavirus middle T antigen. These complexes have a higher tyrosine kinase activity compared with that of unassociated pp60c-src. Genetic analyses have revealed that the carboxy-terminal 15 amino acids of pp60c-src an...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Deletion
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasmids
- Polyomavirus
- Protein-Tyrosine Kinases
- Rats
- Transfection