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Article

The amino terminus of polyomavirus middle T antigen is required for transformation.

Journal of virology - 1 May 1990

Cook D N, Hassell J A

Abstract excerpt

In polyomavirus-transformed cells, pp60c-src is activated by association with polyomavirus middle T antigen. These complexes have a higher tyrosine kinase activity compared with that of unassociated pp60c-src. Genetic analyses have revealed that the carboxy-terminal 15 amino acids of pp60c-src and the amino-terminal half of middle T antigen are required for this association and consequent activation of the...

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Identifiers

PMID: 2157858
DOI: 10.1128/JVI.64.5.1879-1887.1990
PMCID: PMC249341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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