Changes in frequency, morphology, and behavior of tumors induced in mice by a polyoma virus mutant with a specifically altered oncogene.

Abstract excerpt

Alterations in the tumor-inducing ability of a polyoma virus mutant encoding a partially defective middle T oncogene have been investigated. The mutant middle T associates with and activates the tyrosine protein kinase pp60c-src normally but does not promote binding of a second enzyme, phosphatidyl-inositol 3-kinase. Compared with the wild type virus, this mutant shows an altered and reduced ability to induce...

Topics

• Animals
• Enzyme Activation
• Female
• Immunohistochemistry
• In Situ Hybridization
• Incidence
• Male
• Mammary Neoplasms, Experimental
• Mice
• Mice, Inbred C3H
• Mutation