Article
Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.
Nature - 6 Jan 1994
Dilworth S M, Brewster C E, Jones M D, Lanfrancone L, Pelicci G, Pelicci P G
Abstract excerpt
Polyoma virus middle T-antigen converts normal fibroblasts to a fully transformed, tumorigenic phenotype. It achieves this, at least in part, by binding and activating one of the non-receptor tyrosine kinases, pp60c-src, pp62c-yes or pp59c-fyn (reviewed in refs 2 and 3). As a result, middle T-antigen itself is phosphorylated on tyrosine residues, one of which (Tyr 315) acts as a binding site for the SH2 domains...
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