Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.

doi:10.1038/367087a0

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Article

Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.

Nature - 6 Jan 1994

Dilworth S M, Brewster C E, Jones M D, Lanfrancone L, Pelicci G, Pelicci P G

Abstract excerpt

Polyoma virus middle T-antigen converts normal fibroblasts to a fully transformed, tumorigenic phenotype. It achieves this, at least in part, by binding and activating one of the non-receptor tyrosine kinases, pp60c-src, pp62c-yes or pp59c-fyn (reviewed in refs 2 and 3). As a result, middle T-ant...

Topics

Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Amino Acid Sequence
Animals
Antigens, Polyomavirus Transforming
Cell Line
Cell Transformation, Neoplastic
Cell Transformation, Viral
GRB2 Adaptor Protein
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 3-Kinases

Phosphorylation

Phosphotransferases (Alcohol Group Acceptor)

Protein Binding

Proteins

Proto-Oncogene Proteins pp60(c-src)

Rats

Source

Open in PubMed

Identifiers

PMID: 7509037
DOI: 10.1038/367087a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7509037-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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