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Article

A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Hong Y Kate, Mikami Aki, Schaffhausen Brian, Jun Toni, Roberts Thomas M

Abstract excerpt

Previous studies have demonstrated that the specificity of Src homology 2 (SH2) and phosphotyrosine-binding domain interactions are mediated by phosphorylated tyrosines and their neighboring amino acids. Two of the first phosphotyrosine-based binding sites were found on middle T antigen of polyoma virus. Tyr-250 acts as a binding site for ShcA, whereas Tyr-315 forms a binding site for the SH2 domain of the p85...

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Identifiers

PMID: 12881485
DOI: 10.1073/pnas.1432964100
PMCID: PMC170936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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