Article
Polyomavirus middle-T antigen lacking a membrane anchor sequence accumulates in the nucleus.
The Journal of general virology - 1 Jan 1996
Messerschmitt A, Disela C, Dilworth S, Marti A G, Ballmer-Hofer K
Abstract excerpt
Three proteins expressed early in the replicative cycle of polyomavirus also play an essential role during virus-mediated tumorigenesis. One of the proteins, middle-T antigen, has been shown to bind cellular proteins involved in cell signalling such as c-Src, phosphatase 2A, phosphatidylinositol 3-kinase and SHC. Association of middle-T antigen with cellular membranes has been shown to be essential for...
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