Article
Polyomavirus middle-T antigen lacking a membrane anchor sequence accumulates in the nucleus.
The Journal of general virology - 1 Jan 1996
Messerschmitt A, Disela C, Dilworth S, Marti A G, Ballmer-Hofer K
Abstract excerpt
Three proteins expressed early in the replicative cycle of polyomavirus also play an essential role during virus-mediated tumorigenesis. One of the proteins, middle-T antigen, has been shown to bind cellular proteins involved in cell signalling such as c-Src, phosphatase 2A, phosphatidylinositol...
Topics
- 3T3 Cells
- Animals
- Antigens, Polyomavirus Transforming
- Biological Transport
- Cell Line
- Cell Membrane
- Cell Nucleus
- Mice
- Mutation
- Phosphoprotein Phosphatases
- Protein Binding
- Protein Phosphatase 2
- Structure-Activity Relationship