Article
Domains in middle-T antigen that cooperate in polyomavirus-mediated oncogenic transformation.
Virology - 1 Apr 1995
Pérez L, Urich M, Paasinen A, Senften M, Meili R, Ballmer-Hofer K
Abstract excerpt
Middle-T antigen is the oncogenic protein of Polyomavirus and associates with several cellular enzymes involved in signal transduction, e.g., Src tyrosine kinases, phosphatidylinositol 3-kinase (PI 3-kinase), protein phosphatase 2A (PP2A), and Shc, an SH2 domain-containing adapter protein. We have shown earlier that middle-T is a target of a cell cycle-regulated serine/threonine-specific kinase, presumably...
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