A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity.

doi:10.1128/JVI.64.9.4454-4461.1990

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Article

A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity.

Journal of virology - 1 Sept 1990

Druker B J, Ling L E, Cohen B, Roberts T M, Schaffhausen B S

Abstract excerpt

By using a random mutagenesis procedure combined with a recombinant retrovirus vector, mutants of polyomavirus middle T antigen (MTAg) were generated. Three new MTAg mutants with various degrees of transformation competence were more thoroughly characterized. All of the mutants produced a stable...

Topics

1-Phosphatidylinositol 4-Kinase
Animals
Antigens, Polyomavirus Transforming
Cell Line
Cell Transformation, Viral
DNA, Viral
Kinetics
Mice
Mice, Inbred BALB C
Mutation
Phosphorylation
Phosphotransferases
Protein-Tyrosine Kinases
Restriction Mapping
Retroviridae

Source

Open in PubMed Open full text

Identifiers

PMID: 2166824
DOI: 10.1128/JVI.64.9.4454-4461.1990
PMCID: PMC247915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2166824-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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