Article
HLA-DRB1 amino acid disparity is the major stimulus of interleukin-2 production by alloreactive helper T-lymphocytes.
Immunogenetics - 1 Mar 1998
Young N T, Roelen D L, Dallman M J, Morris P J, Welsh K I
Abstract excerpt
The generation of interleukin-2 (IL-2)-mediated helper activity is a central step in the immune response induced by allogeneic histocompatibility antigens, and IL-2-producing helper T-lymphocyte precursor (HTLp) frequencies have been proposed as a measure of alloreactivity in transplant recipient...
Topics
- Amino Acid Sequence
- Amino Acids
- Cells, Cultured
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Testing
- Humans
- Interleukin-2
- Lymphocyte Activation
- Polymerase Chain Reaction
- Stem Cells
- T-Lymphocytes, Helper-Inducer