Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DRB1 amino acid disparity is the major stimulus of interleukin-2 production by alloreactive helper T-lymphocytes.

Immunogenetics - 1 Mar 1998

Young N T, Roelen D L, Dallman M J, Morris P J, Welsh K I

Abstract excerpt

The generation of interleukin-2 (IL-2)-mediated helper activity is a central step in the immune response induced by allogeneic histocompatibility antigens, and IL-2-producing helper T-lymphocyte precursor (HTLp) frequencies have been proposed as a measure of alloreactivity in transplant recipients. We analyzed the influence of HLA-matching on the alloresponse of HTLp in limiting dilution assays derived from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Amino Acids
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Histocompatibility Testing

Share to HLA-DR Antigens

Share to Lymphocyte Activation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9472067
DOI: 10.1007/s002510050363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DRB1 amino acid disparity is the major stimulus of interleukin-2 production by alloreactive helper T-lymphocytes.PMID 9472067Read ↗

HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4+ T cell responses showing immunogenicity of all HLA-DPB1 alleles.Semantic proximity Read ↗

DR non-B1 mismatches influence allogeneic MLR-induced TH1- or TH2-like cytokine responses in rhesus monkeys.Semantic proximity Read ↗

A Proposed Algorithm Predictive for Cytotoxic T Cell AlloreactivitySemantic proximity Read ↗

Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation.Semantic proximity Read ↗

Immunodominance Hierarchies and Gender Bias in Direct TCD8-Cell AlloreactivitySemantic proximity Read ↗

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.Semantic proximity Read ↗

Allele-specific variation in the degeneracy of major histocompatibility complex (MHC) restriction.Semantic proximity Read ↗

Crucial role of the third and fourth hypervariable regions of HLA-DPB1 allelic sequences in the mixed lymphocyte reaction.Semantic proximity Read ↗

HLA DQ and DP locus mismatches and their effect on MLC in HLA class I- and DRB1-matched unrelated patient/donor pairs waiting for allogeneic bone-marrow transplantation.Semantic proximity Read ↗

Is there MHC Class II restriction of the response to MHC Class I in transplant patients?Semantic proximity Read ↗

Frequency, specificity, and phenotype of clonally growing human alloreactive interleukin-2-secreting helper T lymphocyte precursors.Semantic proximity Read ↗

Responses to the H-2Kba mutant involve recognition of syngeneic Ia molecules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.