Article
Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines.
European journal of immunology - 1 Apr 1997
Kovats S, Whiteley P E, Concannon P, Rudensky A Y, Blum J S
Abstract excerpt
Peptides derived from endogenous and exogenous antigens compete for binding and presentation via class II molecules. Studies with mutant B cell lines defective in exogenous antigen presentation suggest that HLA-DM molecules facilitate the interaction of foreign peptides and class II molecules. In...
Topics
- Antigen Presentation
- Antigen-Presenting Cells
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Cell Line
- Epitopes
- HLA-D Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Mutation
- Severe Combined Immunodeficiency