Article
Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM.
Infection and immunity - 1 Oct 1997
Cole B C, Sawitzke A D, Ahmed E A, Atkin C L, David C S
Abstract excerpt
Mycoplasma arthritidis, an agent of rodent arthritis, produces a potent superantigen (SAg), MAM. Previous work established that MAM is presented to T cells by murine H-2E or the homologous human HLA-DR molecules and that lymphocytes lacking a functional H-2E molecule fail to respond to MAM. Recen...
Topics
- Alleles
- Animals
- Antigen Presentation
- Antigens
- Antigens, Bacterial
- H-2 Antigens
- HLA-DQ Antigens
- Histocompatibility Antigens
- Homozygote
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred CBA
- Mice, Transgenic
- Mitogens
- Mycoplasma
- Polymorphism, Genetic