Comparative biochemical properties of normal and activated human ras p21 protein.

doi:10.1038/310644a0

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Article

Comparative biochemical properties of normal and activated human ras p21 protein.

Nature - 1 Jan 2000

McGrath J P, Capon D J, Goeddel D V, Levinson A D

Abstract excerpt

Human Ha-ras1 cDNAs encoding normal and activated p21 polypeptides have been efficiently expressed in Escherichia coli and the biochemical activities associated with each polypeptide compared. In addition to the guanine nucleotide binding activity, normal p21 displays a GTPase activity which is s...

Topics

Cloning, Molecular
DNA
DNA Restriction Enzymes
Escherichia coli
GTP Phosphohydrolases
Guanosine Triphosphate
Humans
Mutation
Neoplasm Proteins
Oncogene Protein p21(ras)
Oncogenes
Phosphorylation
Protein Binding
Proto-Oncogene Proteins p21(ras)
RNA, Messenger
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 6147754
DOI: 10.1038/310644a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6147754-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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