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Article

Comparative biochemical properties of normal and activated human ras p21 protein.

Nature - 1 Jan 2000

McGrath J P, Capon D J, Goeddel D V, Levinson A D

Abstract excerpt

Human Ha-ras1 cDNAs encoding normal and activated p21 polypeptides have been efficiently expressed in Escherichia coli and the biochemical activities associated with each polypeptide compared. In addition to the guanine nucleotide binding activity, normal p21 displays a GTPase activity which is selectively impaired by a mutation which activates its oncogenic potential.

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PMID: 6147754
DOI: 10.1038/310644a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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