Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21.

doi:10.1002/9780470514450.ch2

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Article

Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21.

Ciba Foundation symposium - 1 Jan 1993

Wittinghofer A, Franken S M, Scheidig A J, Rensland H, Lautwein A, Pai E F, Goody R S

Abstract excerpt

Ras (or p21) is the product of the ras proto-oncogene and is believed to be involved in growth-promoting signal transduction. The structure of the guanine nucleotide-binding domain of H-Ras (or p21H-ras) in the triphosphate conformation was determined at very high resolution (1.4 A). All the bind...

Topics

Animals
GTP Phosphohydrolases
Genes, ras
Genetic Code
Humans
Mutation
Protein Conformation
Proto-Oncogene Mas
Proto-Oncogene Proteins p21(ras)

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