Activated conformations of the ras-gene-encoded p21 protein. 2. Comparison of the computed and high-resolution x-ray crystallographic structures of Gly-12 p21.

doi:10.1080/07391102.1993.10508683

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Article

Activated conformations of the ras-gene-encoded p21 protein. 2. Comparison of the computed and high-resolution x-ray crystallographic structures of Gly-12 p21.

Journal of biomolecular structure & dynamics - 1 Apr 1993

Dykes D C, Brandt-Rauf P, Luster S M, Friedman F K, Pincus M R

Abstract excerpt

The ras-oncogene-encoded p21 protein is a G-protein that has been shown to cause the malignant transformation of normal cells and has been implicated in causing human tumors. p21 is thought to be activated by the binding of GTP in place of GDP to the protein. We have previously constructed the th...

Topics

Computer Simulation
Genes, ras
Mutation
Oncogene Protein p21(ras)
Protein Conformation
X-Ray Diffraction

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