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Article

Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant.

Environmental health perspectives - 1 Jun 1991

Wittinghofer F, Krengel U, John J, Kabsch W, Pai E F

Abstract excerpt

The three-dimensional structure of the active guanosine triphosphate (GTP)-analogue-containing complex of the H-ras-encoded p21 has been determined. It was necessary to correct the topology of p21 as published earlier. The structure analysis shows all of the interactions between protein and GTP and how the important cofactor Mg2+ is bound. From the oncogenic mutants of p21 crystallized, a Gly12 to Arg mutation...

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Identifiers

PMID: 1773783
DOI: 10.1289/ehp.919311
PMCID: PMC1568068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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