Article
Decreased GTPase activity of K-ras mutants deriving from human functional adrenocortical tumours.
British journal of cancer - 1 Mar 2000
Lin S R, Hsu C H, Tsai J H, Wang J Y, Hsieh T J, Wu C H
Abstract excerpt
Our previous studies have shown that seven out of 15 patients with adrenocortical tumours contained K-ras gene mutation. In addition, the mutation type was a multiple-site mutation, and the hot spots were located at codons 15, 16, 18 and 31, which were different from those reported before (codons 12, 13 and 61). To understand whether the mutation hot spots in human adrenocortical tumours were associated with...
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