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Article

Identification of a nucleotide exchange-promoting activity for p21ras.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Downward J, Riehl R, Wu L, Weinberg R A

Abstract excerpt

The biological activity of proteins encoded by the ras family of oncogenes is dependent on whether they are bound to GTP or GDP: the type of nucleotide bound is dependent on the rate of GTP hydrolysis (promoted by the GTPase-activating protein, GAP) and the rate of nucleotide exchange with cytosolic pools. A protein that stimulates the rate of exchange of guanine nucleotide on p21ras has been identified and...

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Identifiers

PMID: 2116014
DOI: 10.1073/pnas.87.15.5998
PMCID: PMC54457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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