Identification of a nucleotide exchange-promoting activity for p21ras.

doi:10.1073/pnas.87.15.5998

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Article

Identification of a nucleotide exchange-promoting activity for p21ras.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Downward J, Riehl R, Wu L, Weinberg R A

Abstract excerpt

The biological activity of proteins encoded by the ras family of oncogenes is dependent on whether they are bound to GTP or GDP: the type of nucleotide bound is dependent on the rate of GTP hydrolysis (promoted by the GTPase-activating protein, GAP) and the rate of nucleotide exchange with cytosolic pools. A protein that stimulates the rate of exchange of guanine nucleotide on p21ras has been identified and...

Topics

Chromatography, Gel
Chromatography, Ion Exchange
Female
GTP-Binding Proteins
GTPase-Activating Proteins
Genes, ras
Guanine Nucleotides
Guanosine Diphosphate
Guanosine Triphosphate
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macromolecular Substances

Mutation

Oncogene Protein p21(ras)

Placenta

Pregnancy

Proteins

ras GTPase-Activating Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 2116014
DOI: 10.1073/pnas.87.15.5998
PMCID: PMC54457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2116014-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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