Article
Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell - 10 Aug 1990
Krengel U, Schlichting I, Scherer A, Schumann R, Frech M, John J, Kabsch W, Pai E F, Wittinghofer A
Abstract excerpt
The X-ray structures of the guanine nucleotide binding domains (amino acids 1-166) of five mutants of the H-ras oncogene product p21 were determined. The mutations described are Gly-12----Arg, Gly-12----Val, Gln-61----His, Gln-61----Leu, which are all oncogenic, and the effector region mutant Asp...
Topics
- Adenosine Triphosphate
- Amino Acid Sequence
- Binding Sites
- Cell Transformation, Neoplastic
- Models, Molecular
- Mutation
- Oncogene Protein p21(ras)
- Protein Conformation
- X-Ray Diffraction