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Article

Divergent Clonal Trajectories of FLT3-ITD in Acute Myeloid Leukemia and Their Clinical and Transcriptomic Associations.

Hematological oncology - 1 Sept 2026

Tsai Xavier Cheng-Hong, Chang Yu-Sung, Tien Feng-Ming, Lo Min-Yen, Kuo Yuan-Yeh, Tseng Mei-Hsuan, Peng Yen-Ling, Yao Chi-Yuan, Yao Szu-Chi, Lin Chien-Chin, Ko Bor-Sheng, Yao Ming, Tien Hwei-Fang, Hou Hsin-An, Chou Wen-Chien

Abstract excerpt

FLT3-ITD occurs in approximately 20%-25% of cases of adult AML and is associated with increased relapse risk and shorter survival. FLT3-ITD status informs AML risk at diagnosis, but its dynamic changes during disease evolution are not well defined. We hypothesized that divergent FLT3-ITD clonal trajectories are shaped by preexisting molecular features detectable at diagnosis. We analyzed 319 intensively treated...

Read the complete abstract on PubMed

Topics

Humans
fms-Like Tyrosine Kinase 3
Nucleophosmin
Leukemia, Myeloid, Acute
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Middle Aged

Adult

Transcriptome

Clonal Evolution

Aged

DNA Methyltransferase 3A

Prognosis

DNA (Cytosine-5-)-Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 42770524
DOI: 10.1002/hon.70261
PMCID: PMC13595497

Genes

FLT3
DNMT3A
NPM1
ELN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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