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Article

Clonal architecture of FLT3-ITD and acquired 13q uniparental disomy define prognostic heterogeneity and therapeutic vulnerabilities in acute myeloid leukemia.

Neoplasia (New York, N.Y.) - 1 Feb 2026

Lai Anli, Liu Wenbing, Mei Yihan, Zhang Qimin, Zhang Junping, Tang Kejing, Rao Qing, Gu Runxia, Feng Sizhou, Wang Ying, Wang Min, Wei Hui, Mi Yingchang, Qiu Shaowei, Wang Jianxiang

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by the sequential accumulation of genetic mutations in hematopoietic stem/progenitor cells (HSPCs). The FLT3-ITD mutation, occurring in 20-30 % of AML cases, typically emerges as a late event. Despite its established association with adverse prognosis, significant outcome heterogeneity persists in FLT3-ITD AML. The clonal origin of FLT3-ITD may serve as a critical...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41411742
DOI: 10.1016/j.neo.2025.101264
PMCID: PMC12808504

Genes

NPM1
DNMT3A
FLT3
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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