Real world molecular characterisation and clonal evolution of acute myeloid leukaemia reveals therapeutic opportunities and challenges.

doi:10.1016/j.pathol.2022.07.019

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Article

Real world molecular characterisation and clonal evolution of acute myeloid leukaemia reveals therapeutic opportunities and challenges.

Pathology - 1 Feb 2023

Nelles Ricky, Seymour Louise, Richmond Joshua, Lane Steven

Abstract excerpt

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with poor prognosis. Increasing understanding of the molecular mechanisms driving clonal proliferation has resulted in advancements in classification and available therapeutic targets. Fms-related tyrosine kinase 3 (FLT3) mu...

Topics

Humans
Neoplasm Recurrence, Local
Leukemia, Myeloid, Acute
Mutation
Translocation, Genetic
Clonal Evolution
fms-Like Tyrosine Kinase 3
Prognosis

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