Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.

doi:10.1182/blood.2020007626

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Article

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.

Blood - 3 Jun 2021

Schmalbrock Laura K, Dolnik Anna, Cocciardi Sibylle, Sträng Eric, Theis Frauke, Jahn Nikolaus, Panina Ekaterina, Blätte Tamara J, Herzig Julia, Skambraks Sabrina, Rücker Frank G, Gaidzik Verena I, Paschka Peter, Fiedler Walter, Salih Helmut R, Wulf Gerald, Schroeder Thomas, Lübbert Michael, Schlenk Richard F, Thol Felicitas, Heuser Michael, Larson Richard A, Ganser Arnold, Stunnenberg Hendrik G, Minucci Saverio, Stone Richard M, Bloomfield Clara D, Döhner Hartmut, Döhner Konstanze, Bullinger Lars

Abstract excerpt

In the international randomized phase 3 RATIFY (Randomized AML Trial In FLT3 in patients less than 60 Years old) trial, the multikinase inhibitor midostaurin significantly improved overall and event-free survival in patients 18 to 59 years of age with FLT3-mutated acute myeloid leukemia (AML). Ho...

Topics

Adolescent
Adult
Aged
Clonal Evolution
Female
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Staurosporine

Tandem Repeat Sequences

Exome Sequencing

fms-Like Tyrosine Kinase 3

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Identifiers

PMID: 33598693
DOI: 10.1182/blood.2020007626
PMCID: PMC8233666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-33598693-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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