Article
TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity.
Nature communications - 21 Aug 2026
Tomecki Rafał, Drabko Małgorzata, Siek Małgorzata, Matykiewicz Maria, Ludwinek Miłosz, Borowski Łukasz S, Jurkiewicz Aneta, Kobyłecki Kamil, Jabłońska Agnieszka, Cysewski Dominik, Malinowska Agata, Bakun Magdalena, Płoski Rafał, Szczęsny Roman J, Tudek Agnieszka
Abstract excerpt
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners using comparative label-free mass spectrometry. The TTC33-associated network (TAN) comprises WDR61, CCDC97, UNG1/2,...
Read the complete abstract on PubMedTopics
- Humans
- Genomic Instability
- RNA Splicing Factors
- Protein Binding
- Membrane Proteins