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Article

Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.

The Journal of biological chemistry - 1 Dec 2022

Sheehan Colin T, Hampton Thomas H, Madden Dean R

Abstract excerpt

Intrinsically disordered proteins (IDPs) often coordinate transient interactions with multiple proteins to mediate complex signals within large protein networks. Among these, the IDP hub protein G3BP1 can form complexes with cytoplasmic phosphoprotein Caprin1 and ubiquitin peptidase USP10; the resulting control of USP10 activity contributes to a pathogenic virulence system that targets endocytic recycling of the...

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Identifiers

PMID: 36183834
DOI: 10.1016/j.jbc.2022.102552
PMCID: PMC9723946

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