Article
Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH.
Molecular cell - 3 Sept 2015
Luo Jie, Cimermancic Peter, Viswanath Shruthi, Ebmeier Christopher C, Kim Bong, Dehecq Marine, Raman Vishnu, Greenberg Charles H, Pellarin Riccardo, Sali Andrej, Taatjes Dylan J, Hahn Steven, Ranish Jeff
Abstract excerpt
TFIIH is essential for both RNA polymerase II transcription and DNA repair, and mutations in TFIIH can result in human disease. Here, we determine the molecular architecture of human and yeast TFIIH by an integrative approach using chemical crosslinking/mass spectrometry (CXMS) data, biochemical analyses, and previously published electron microscopy maps. We identified four new conserved "topological regions"...
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