Article

A synthesis of over 9,000 mass spectrometry experiments reveals the core set of human protein complexes

2016-12-07

Abstract excerpt

Macromolecular protein complexes carry out many of the essential functions of cells, and many genetic diseases arise from disrupting the functions of such complexes. Currently there is great interest in defining the complete set of human protein complexes, but recent published maps lack comprehensive coverage. Here, through the synthesis of over 9,000 published mass spectrometry experiments, we present hu.MAP, the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a09e6aaa-71d6-56bf-9dfe-384f01b43457
DOI: 10.1101/092361

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A synthesis of over 9,000 mass spectrometry experiments reveals the core set of human protein complexesDOI 10.1101/092361Read

hu.MAP 2.0: Integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assembliesSemantic proximity Read

hu.MAP3.0: Atlas of human protein complexes by integration of > 25,000 proteomic experimentsSemantic proximity Read

Structural insights into predicted protein-protein interactions and protein complexes in the human proteome.Semantic proximity Read

DirectContacts2: A network of direct physical protein interactions derived from high-throughput mass spectrometry experimentsSemantic proximity Read

Multimodal cell maps as a foundation for structural and functional genomics.Semantic proximity Read

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteinsSemantic proximity Read

A human phenome-interactome network of protein complexes implicated in genetic disorders.Semantic proximity Read

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseasesSemantic proximity Read

A wiring of the human nucleolus.Semantic proximity Read

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC)Semantic proximity Read

Quantitative behavior of protein complexes in human cellsSemantic proximity Read

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complexSemantic proximity Read