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Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network

28 May 2020

Abstract excerpt

Despite the continued analysis of HDAC inhibitors in clinical trials, the heterogeneous nature of the protein complexes they target limits our understanding of the beneficial and off-target effects associated with their application. Among the many HDAC protein complexes found within the cell, Sin3 complexes are conserved from yeast to humans and likely play important roles as regulators of transcriptional...

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PMID: 32467258
DOI: 10.1074/mcp.ra120.002078

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