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Article

Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.

Antimicrobial agents and chemotherapy - 1 Mar 2002

Vakulenko Sergei, Golemi Dasantila

Abstract excerpt

A derivative of the TEM-1 beta-lactamase producing clinically significant levels of resistance to ceftazidime and beta-lactamase inhibitors in the presence of penicillins was generated following five rounds of DNA shuffling and selection. This complex mutant enzyme contained three amino acid substitutions including those of residues 104 and 276 that are known to produce extended-spectrum resistance and,...

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Identifiers

PMID: 11850243
DOI: 10.1128/AAC.46.3.646-653.2002
PMCID: PMC127477

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.PMID 11850243Read ↗

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