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Article

Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases.

International journal of antimicrobial agents - 1 Jan 2022

Cheng Qipeng, Cheung Yan Chu, Chan Edward Wai Chi, Wong Kwok Yin, Chen Sheng

Abstract excerpt

The TEM-1 β-lactamase can only cleave penicillin and the first-generation cephalosporins but it has evolved to become active against second-, third- and fourth-generation drugs. Through sequence analysis of natural TEM variants and those created by mutagenesis experiments, we described two distinct evolution routes of TEM-1 that has generated over 220 enzyme variants. One began with the Gly238Ser alteration and...

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PMID: 34929294
DOI: 10.1016/j.ijantimicag.2021.106498

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