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Article

Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase.

The Journal of biological chemistry - 25 Jan 2013

Sun Song, Zhang Wei, Mannervik Bengt, Andersson Dan I

Abstract excerpt

The extensive use and misuse of antibiotics during the last seven decades has led to the evolution and global spread of a variety of resistance mechanisms in bacteria. Of high medical importance are β-lactamases, a group of enzymes inactivating β-lactam antibiotics. Metallo-β-lactamases (MBLs) ar...

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Identifiers

PMID: 23209299
DOI: 10.1074/jbc.M112.430199
PMCID: PMC3554903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23209299-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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