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Article

Suppression of antibiotic resistance evolution by single-gene deletion.

Scientific reports - 6 Mar 2020

Horinouchi Takaaki, Maeda Tomoya, Kotani Hazuki, Furusawa Chikara

Abstract excerpt

Antibiotic treatment generally results in the selection of resistant bacterial strains, and the dynamics of resistance evolution is dependent on complex interactions between cellular components. To better characterize the mechanisms of antibiotic resistance and evaluate its dependence on gene regulatory networks, we performed systematic laboratory evolution of Escherichia coli strains with single-gene deletions...

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Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Bacterial

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Identifiers

PMID: 32144279
DOI: 10.1038/s41598-020-60663-6
PMCID: PMC7060189

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