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Article

BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.

Current opinion in immunology - 1 Dec 2015

Metzler Genita, Kolhatkar Nikita S, Rawlings David J

Abstract excerpt

The establishment of a diverse B cell repertoire requires fine-tuning of antigen receptor selection during development in order to permit sufficient diversity while reducing the potential for autoimmunity. In this review, we highlight recent studies demonstrating the central role of the B cell antigen receptor (BCR), in coordination with other key pro-survival signals mediated by CD40, BAFF-R, TACI and/or TLRs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26605835
DOI: 10.1016/j.coi.2015.10.001
PMCID: PMC4679457

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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