Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TACI‐dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus

7 Mar 2017

Abstract excerpt

Autoantibodies contribute to the development of systemic lupus erythematosus (SLE). APRIL (a proliferation‐inducing ligand), a member of the TNF superfamily, regulates plasma‐cell survival and binds to TACI (transmembrane activator CAML interactor) and BCMA (B‐cell maturation antigen). We previously showed that APRIL blockade delayed disease onset in lupus‐prone mice. In order to evaluate the role of APRIL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Systemic Lupus Erythematosus Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28267197
DOI: 10.1002/eji.201646630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TACI‐dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosusPMID 28267197Read ↗

TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.Semantic proximity Read ↗

B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.Semantic proximity Read ↗

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.Semantic proximity Read ↗

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.Semantic proximity Read ↗

APRIL-deficient mice have normal immune system development.Semantic proximity Read ↗

Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice.Semantic proximity Read ↗

Impaired IgA class switching in APRIL-deficient mice.Semantic proximity Read ↗

Spontaneous CD4+ T Cell Activation and Differentiation in Lupus-Prone B6.Nba2 Mice Is IFNAR-Independent.Semantic proximity Read ↗

The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice.Semantic proximity Read ↗

Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice.Semantic proximity Read ↗

Complement C4A Regulates Autoreactive B Cells in Murine LupusSemantic proximity Read ↗

Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.