Article
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF.
The Journal of biological chemistry - 29 Aug 2003
Pelletier Marc, Thompson Jeffrey S, Qian Fang, Bixler Sarah A, Gong Dahai, Cachero Teresa, Gilbride Kevin, Day Eric, Zafari Mohammad, Benjamin Chris, Gorelik Leonid, Whitty Adrian, Kalled Susan L, Ambrose Christine, Hsu Yen-Ming
Abstract excerpt
BAFF is considered a therapeutic target because dysregulated production of BAFF can induce systemic lupus erythematosus-like phenotype in mice, and elevated levels of BAFF are associated with disease severity in systemic lupus erythematosus and rheumatoid arthritis patients. Fc fusion decoy receptors, BCMA-Fc and BAFF-R-Fc, are therapeutic candidates for blocking BAFF. While studying their interactions with BAFF,...
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