Article

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/Taz

2019-10-25

Abstract excerpt

<h4>Background & Aims</h4> Activation of MYC and CTNNB1 (encoding β-catenin) can co-occur in liver cancer, but how these oncogenes cooperate in tumorigenesis remains unclear. <h4>Approach & Results</h4> We generated a mouse model allowing conditional activation of MYC and WNT/β-catenin signaling (through either β-catenin activation or Apc loss) upon expression of CRE recombinase in the liver, and monitored th...

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Literature Corpus work: e966d8ce-e31a-5822-86bf-c62582366445
DOI: 10.1101/819631

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