Article

Two axes of drug transcriptional response, and a mechanistic correlate that organizes them: a conservation–divergence audit of Tahoe-100M

2026-07-23

Abstract excerpt

<title>Abstract</title> <p> Some drugs produce nearly the same transcriptional fingerprint in every cell line; others act only where the biological context permits, so their response shifts from one background to the next. Which of these a drug is — and what decides it — is rarely measured directly, because large-scale drug-perturbation atlases are used mostly to <italic>train</italic> and <italic>benchmark</...

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Literature Corpus work: c6165c83-ce22-5eba-9c7f-6824eb6b50ed
DOI: 10.21203/rs.3.rs-10448056/v1

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