Article
Quantifying the Genetic Correlation between Multiple Cancer Types.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2017
Lindström Sara, Finucane Hilary, Bulik-Sullivan Brendan, Schumacher Fredrick R, Amos Christopher I, Hung Rayjean J, Rand Kristin, Gruber Stephen B, Conti David, Permuth Jennifer B, Lin Hui-Yi, Goode Ellen L, Sellers Thomas A, Amundadottir Laufey T, Stolzenberg-Solomon Rachael, Klein Alison, Petersen Gloria, Risch Harvey, Wolpin Brian, Hsu Li, Huyghe Jeroen R, Chang-Claude Jenny, Chan Andrew, Berndt Sonja, Eeles Rosalind, Easton Douglas, Haiman Christopher A, Hunter David J, Neale Benjamin, Price Alkes L, Kraft Peter
Abstract excerpt
Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the overall shared heritability across cancers. Quantifying the extent to which two distinct cancers share genetic origin will give insights to shared biological mechanisms underlying cancer and inform...
Topics
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Male