EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

Abstract excerpt

Endocrine therapies targeting the estrogen receptor (ER/ ESR1 ) are the cornerstone to treat ER-positive breast cancers patients, but resistance often limits their effectiveness. Understanding the molecular mechanisms is thus key to optimize the existing drugs and to develop new ER-modulators. Notable progress has been made although the fragmented way data is reported has reduced their potential impact. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

• Biomarkers, Tumor
• Breast Neoplasms
• Estrogen Receptor alpha
• Exome Sequencing
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Genital Neoplasms, Female
• Mutation, Missense

Identifiers and source

Literature Corpus work

a01edc5d-16b3-598b-9441-390ffdd1e540

DOI

10.1101/2024.06.28.601163