Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity.

doi:10.1038/s41467-026-76373-y

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Article

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity.

Nature communications - 10 Aug 2026

Illendula Abhinav, Hewett Charles K, Hayata Yuki, Strathearn Lauren S, He Guoshun, Carballo-Botinas Laia, Navas-Sanz Sara, Niqui-Capdevila Maria, Garcia-Santos Avril, Bernabé-Pérez Rocío, Bustillo-Bustos Alejandra, Mikoyan Ani, Helm Eleanor, Gonzalez-Sorribes Marina, de Prisco Nicola, Das Aasthika, Zhang Yuanguangyan, Rossell David, Slifker Michael, Akizu Naiara, Sun Beicheng, Font-Burgada Joan

Abstract excerpt

Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma but are widely considered weak or cooperative drivers, raising the question of how their oncogenic potential is contextually regulated. Aging and...

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Topics

Animals
beta Catenin
Liver
Male
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Carcinogenesis

Liver Neoplasms

Hepatocytes

NF-E2-Related Factor 2

Endoplasmic Reticulum Stress

Proto-Oncogene Proteins c-akt

Carcinoma, Hepatocellular

Oxidative Stress

Aging

Cell Transformation, Neoplastic

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 42706261
DOI: 10.1038/s41467-026-76373-y
PMCID: PMC13550535

Provenance

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