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Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury

4 Jan 2025

Abstract excerpt

BACKGROUND & AIMS: mice through genetic excision of hepatocyte Mdm2. METHODS: (immune competent and deficient strains) mice. Engraftment kinetics, donor cell engraftment and host liver function were assessed. Paired transcriptomic and proteomic analyses were performed on healthy vs. senescent mouse hepatocytes. RESULTS: We found inhibition of host hepatocyte proliferation and liver injury is a requirement for...

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PMID: 39755157
DOI: 10.1016/j.jhep.2024.12.039

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